Mankind discover the existence of the Vampire and Lycan species and they started a war of racial extermination. When Selene meets Michael in the harbor, they are hit by a grenade and Selene had fainted. Twelve years later, Selene awakens from a cryogenic sleep antigen laboratory and vampires meet David. She learned that she was the subject of the scientist Dr. Jacob Lane and the Vampire and Lycan species were practically excluded from Earth. But Selene is still connected to Michael and has visions that she believes that Michael's vision belongs. However, she got a surprise and found that she had a daughter named Eve was strong yet in the laboratory. Now Selene and David must protect Eve against the Lycans that intend to use her to inoculate their species against silver.